Early phase acute AD (aAD) is characterized by erythema, eczema, and pruritus, all caused by a predominant TH2-mediated immune response via increased production of interleukin (IL)-4, IL-5, and IL-13, and a decrease in production of IL-12 and interferon-gamma (IFN-γ) [5]. Here, IL4 is linked to Alzheimer disease.