NLRP3 and rheumatoid arthritis: For example, on the one hand, ROS can induce the activation of NLRP3 inflammasome, which interacts with NF-κB signal [56], and on the other hand, it mediates the activation of MAPK pathway [57], thereby promoting the generation and secretion of inflammatory cytokines and mediators, exacerbating the inflammatory response and joint damage of RA.