SPARC and non-small cell lung carcinoma: The most downregulated genes in CAF-S5 versus CAF-S1 in early NSCLC included TAGLN (transgelin), TPM2 (tropomyosin 2), SPARC (secreted protein acidic and cysteine rich) and MYL9 (myosin light chain 9) (Fig. 5b, normalised counts shown in Fig. S6).