TNFRSF12A and glioblastoma: In addition, the fibroblast growth factor-inducible 14 (Fn14) receptor represents a promising target for CAR therapy, since Fn14 itself and its cytokine ligand, the tumor necrosis factor-like weak inducer of apoptosis (TWEAK), have been detected as key players in proliferation, migration, invasion, and resistance to chemotherapy in various solid tumors, including GBM [34, 35].