IDH1 and neoplasm: In tumor cells, aberrant cell ‐ECM interaction elicits altered signal transduction and often results in resistance to chemotherapy drugs or molecular agents, and is known as cell adhesion‐mediated drug resistance (CAM‐DR).[33] IDH1 and OCT6 showed enhanced binding at the canonical focal adhesion target gene, COL6A1 (Figure 6h), which was further supported by the ChIP analysis (Figure 6i; Figure S6b, Supporting Information).