We then depleted IDH1 in endometrial cancer cells and rescued these cells with Flag‐tagged shRNA‐resistant (r) IDH1 wild‐type (WT), T77A and T157A (Figure S1b, Supporting Information), and found that only the T77A mutation failed to be phosphorylated after MPA administration (Figure 1e). The gene discussed is IDH1; the disease is endometrial cancer.