However, in certain categories of illnesses, abnormal protein degradation serves as a pathogenic mechanism such as cystic fibrosis transmembrane conductance regulator (CFTR) in cystic fibrosis (105), p53 in cancer cells (106), and insufficient expression of other disease prevention proteins because of accelerated protein degradation (107, 108, 109). This evidence concerns the gene CFTR and cystic fibrosis.