To further understand the generation of TPCS, the scRNA expression data of normal urothelium basal cells (BsP, Bs1, Bs2, and Bs3, Figure S9, Supporting Information) and cancer cells (FPCS, TPCS, and basal cancer cells “Ca”) associated with the same class of sample that are strictly mappable to phenotypically similar scATAC clusters were re‐analyzed (Figure 4A). This evidence concerns the gene IBSP and cancer.