In the ENTPD1/ITGAE double positive (tumor‐reactive, tr) population, local TCR clonal expansion and PD‐1 expression were used to classify the following four clusters of effector T cells (Teff): the TOP2A+ proliferating prTeff, IFNGhigh trTeff, IFNGlow trTeff, and IFNG−/CXCR6+ trTeff (trTeff‐CXCR6) (Figure S13B, Supporting Information). The gene discussed is TOP2A; the disease is neoplasm.