For the CD8+ T cell population, globally‐expanded cells including the immature, non‐ PDCD1 (PD‐1)‐expressing TEM clusters, PBMC‐Tem XCL, (KLRG1+, PRF1+, and XCL+ populations), as well as PD‐1 expressing actTeff (GZMK+), do not express the tumor‐reactiveness markers ENTPD1 (CD39) and ITGAE (CD103), and hence are considered non‐tumor‐reactive (Figure S13B, Supporting Information). Here, GZMK is linked to neoplasm.