Limitations of this study include: 1) a lack of paired single cell ChrAcc and transcriptome profiling, resulting in many of the multimodal joint analyses relying on bioinformatic inference; 2) a lack of in vivo experiments to validate the direct derivation of cancer TPCS from BsP; 3) a lack of in vitro experiments to validate the proposed mechanism; and 4) a lack of detailed analysis on how differential transcription factor activity regulates gene expression, putatively supported by ChIP‐exo and CUT&Tag experiments. The gene discussed is IBSP; the disease is cancer.