CCNB1 and cancer: We assessed the DNA methylation status of CCNB1 using the UALCAN database and observed a significant decrease in methylation levels in 14 cancer types, including BLCA, HNSC, PRAD, KIRC, UCEC, KIRP, COAD, LIHC, SARC, LUAD, TGCT, ESCA, LUSC, and THCA, compared to their corresponding normal tissues (Figure 8).