PDCD1 and neoplasm: In another mouse model of triple-negative breast cancer (TNBC), tumor growth was significantly inhibited in the LAG-3 and PD-1 double-blocking mice, and the final tumor volume or weight was also significantly smaller in this group than in the PD-1 or LAG-3 single-blocking group (P < 0.05) and PBS control group (P < 0.001) after 28 days of treatment and observation [67].