IL-1β, IL-6 and TFN-α are particularly relevant, contributing to cancer and the majority of inflammatory disorders, including cardiovascular disorders, rheumatoid arthritis and several other autoimmune inflammatory diseases, pulmonary inflammation, as well as type-2 diabetes mellitus (Zhao et al. 2013; Turner et al. 2014; Jiang et al. 2020). Here, IL1B is linked to rheumatoid arthritis.