While nuclear TFEB immunoreactivity in aSyn-positive neurons was reduced compared to controls in patients with either iLBD, sPD/DLB and GBA-PD/DLB (Fig. 1k), we observed a trend for lower nuclear immunoreactivity scores also in neurons without apparent aSyn pathology in the iLBD group (p = 0.104; Wald Chi-Square: 2.646; B = − 0.543; 95% CI [− 1.197: 0.111]) and in the GBA-PD/DLB group (p = 0.071; Wald Chi-Square: 3.253; B = − 0.705; 95% CI [− 1.470:0.061] compared to cells in control cases. The gene discussed is TFEB; the disease is Parkinson disease.