Research on diffuse large B-cell lymphoblastoma (DLBCL) proposed that approximately 40% of primary testicular DLBCL (PT-DLBCL) patients were accompanied by NFKBIZ somatic cell mutations, and the abnormal expression of NFKBIZ promoted PT-DLBCL advancement [7, 8]. Here, NFKBIZ is linked to diffuse large B-cell lymphoma.