As shown in Fig. 8E, in HCC cells transfected with sh-NFKBIZ, the expressions of pro-apoptotic proteins including Caspase3/c-Caspase3 and Bax were decreased, while the expressions of anti-apoptotic markers (Survivin and BCL-2) were enhanced. The gene discussed is BIRC5; the disease is hepatocellular carcinoma.