The signaling pathways regulated by activating T cell nuclear factor (NFAT) and activating protein (AP) inhibit the proliferation of CD + 8 T cells and CD + 4 T cells, and reduce the levels of interleukin-2 (IL-2) and interferon- γ (IFN)- γ) the tumor’s secretion leads to tumor immune escape [46]. Here, IL2 is linked to neoplasm.