DLD and diffuse large B-cell lymphoma: Cuprotosis through direct binding of copper with the lipoylation components of the TCA cycle, lipoylation is a key regulatory factor in cuprotosis, and DLD is a key gene encoding components of the lipoylation pathway, therefore, DLD regulates cuprotosis by encoding components of the lipoylation pathway (Figure S3) [10].We have demonstrated differential expression of DLD in DLBCL in organizational samples, peripheral blood samples, and single cells.