Therefore, the mechanosensitive Ca2+-permeable Piezo1 channel could be used by GBM cells to sense mechanical stimuli from the tumor microenvironment, in the form of local deformation of the plasma membrane (i.e., stretch, indentation, invagination etc.), and to induce an increase in cytoplasmic Ca2+ that enables cell volume and shape modifications necessary for the cell to invade the healthy brain parenchyma, through activation of KCa channels and regulation of actin cytoskeletal polymerization. This evidence concerns the gene CSN3 and glioblastoma.