IRF4 and neoplasm: Genome-wide transcriptional profiling further confirmed a regulatory network orchestrated by Batf, Irf4, Runx3, and T-bet, of which Irf family genes were indispensable factors that cooperate with Batf to regulate T cell survival and anti-tumour responses, increasing chromatin accessibility and transcription loci of T cell effector function and persistency under infections [157, 162, 164].