Some peripheral cytokines frequently studied in cardiovascular disease such as matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-3 (MMP-3), osteopontin, and pentraxin-3 can be used as markers to reflect vascular inflammation, endothelial function, or permeability of the BBB [5–9]. The gene discussed is SPP1; the disease is cardiovascular disorder.