When comparing the genetic models of APOA5 variants, the dominant models of the three variants of the APOA5 gene showed a significant association with MetS: carrying a G allele of rs2266788 (OR, 95% CI = 1.37, 1.03–1.81, P = 0.029, A/G + G/G vs. A/A), carrying a G allele of rs662799 (OR, 95% CI = 1.74, 1.31–2.31, P < 0.001, A/G + GG vs. A/A), and carrying a C allele of rs651821 (OR, 95% CI = 1.76, 1.32–2.33, P < 0.001, T/C + C/C vs. T/T). This evidence concerns the gene APOA5 and metabolic syndrome.