While they share histological features with other genetic types of supratentorial ependymomas (such as the eosinophilic granular bodies found in YAP1-fused cases, and a subset has been found to have the clear cell component seen in ZFTA-fused cases), NET-PLAGL1 seem to be an enriched form of the ancient nosology known as “mixed ependymomas–subependymomas”. The gene discussed is PLAGL1; the disease is ependymoma.