In this study, we found that rs7198975 and rs1774266 of the HYDIN gene were significantly related to ASD (OR = 1.003–1.461, P = 0.04621), which was similar to the results of Liu et al. (NM_001198542:c.A2207C) [42].In addition, Gao et al. also found that the loss of HYDIN function increased the risk of ASD [43]. Here, HYDIN is linked to atrial septal defect.