To enhance the prognostic efficacy of FNDC3B in PC, we developed a nomogram incorporating radiation therapy, primary therapy outcome, histologic grade, residual tumor status, anatomic neoplasm subdivision along with FNDC3B expression to accurately predict the 1-, 2-, and 3-year OS for PC patients (Fig. 6A). The gene discussed is FNDC3B; the disease is pachyonychia congenita.