Subsequently, we further compared FNDC3B expression via TCGA & GTEx database and six GEO datasets (GSE16515, GSE28735, GSE62165, GSE62452, GSE15471 and GSE101448), which consistently showed higher levels of FNDC3B expression in PC tissues than those observed in normal pancreatic tissues (P < 0.05, Fig. 1C–I). Here, FNDC3B is linked to pachyonychia congenita.