FNDC3B and neoplasm: High FNDC3B expression in PC was significantly related to advanced pathological T stage (T3 & T4 vs. T1 & T2, P = 0.03), positive lymph node involvement (N1 vs. N0, P = 0.01), advanced pathological stage (stage II, stage III &stage IV vs. stage I, P = 0.02), higher histologic grade (G2 vs. G1, P = 0.0042; G3 & G4 vs. G1, P = 0.0035), younger age (< = 65 vs. > 65, P = 0.0037), residual tumor (R1 & R2 vs. R0, P = 0.04), OS event (Dead vs. Alive, P = 0.0016), DSS event (Dead vs. Alive, P < 0.0001), PFI event (Dead vs. Alive, P = 0.0026) (Fig. 4A–I).