The COL7A1 c.6163G > A patient phenotype was less severe with the denuded skin only located on the lower limbs, while NGS analysis of the KRT14 patient revealed a c.377T > G variant having more widespread blisters that affected the hands, feet, back, buttocks, nose, and oral mucosa, which gave more room for bacterial penetration, leading to unresolved septicemia and ultimately leading to his death. The gene discussed is COL7A1; the disease is Sepsis.