More recently, Sridaran et al. observed that oncogenic tyrosine kinase Activated CDC42 kinase 1 (ACK1) inhibited CXCL10 expression via the EZH2/H3K27 methylation-dependent manner and consequently reduced CD8 T cell infiltration in PCa tumors [7, 35]. The gene discussed is EZH2; the disease is posterior cortical atrophy.