MAP2K1 and neoplasm: Matrix metalloprotein 9 (MMP9) and matrix metalloprotein 13 (MMP13) belong to the family of metalloproteinases that degrade the extracellular matrix.MMP9 and MMP13 have been reported to play crucial roles in the regulation of tumor vasculogenic mimicry [32–34].Mitogen- Activated Protein Kinase 1 (MAPK1) is a key signaling hub that integrates extracellular signals and plays an important regulatory role in tumor cell proliferation, differentiation, senescence, and drug resistance, and is of wide interest in a variety of diseases [35, 36].