Per SD increase in serum albumin levels was suggestively associated with a 26.3% lower risk of PHD (OR = 0.737, 95% CI [0.622 − 0.874], P < 0.001), 0.78% lower risk of AF (OR = 0.922, 95% CI [0.870 − 0.977], P = 0.006), and can translate into lower risk of VTE (OR = 0.993, 95% CI [0.991 − 0.995], P < 0.001), and Stroke (OR = 0.997, 95% CI [0995 − 0.999], P = 0.002), but not with HF (OR = 1.001, 95% CI [1.000 − 1.002], P = 0.293), CAD (OR = 1.001, 95% CI [0.917 − 1.093], P = 0.976), and T2DM (OR = 1.045, 95% CI [0.940 − 1.161], P = 0.416). The gene discussed is ALB; the disease is Stroke.