Genetically predicted serum albumin levels were associated with PHD (odds ratio = 0.737, 95% CI = 0.622 − 0.874, P < 0.001), AF (odds ratio = 0.922, 95% CI = 0.870 − 0.977, P = 0.006), VTE (odds ratio = 0.993, 95% CI = 0.991 − 0.995, P < 0.001), and Stroke (odds ratio = 0.997, 95% CI = 0.995 − 0.999, P = 0.002). This evidence concerns the gene ALB and atrial fibrillation.