TP53 and neoplasm: Next, we set out to assess the functional consequences of reduced mutant p53 R273H levels upon knockout of FBXO42 or CCDC6. Since accumulated mutant p53 is required for many gain-of-function properties, reducing its level may lead to suppression of tumor growth and attenuation of invasion and metastasis formation (Alexandrova et al, 2015; Freed-Pastor and Prives, 2012; Oren and Rotter, 2010).