Interestingly, knock-in mouse models of p53 and Li-Fraumeni patients carrying germline p53 GOF mutations highly express mutant p53 specifically in tumor cells, but show low or undetectable levels of mutant p53 in the surrounding, phenotypically normal tissues (Lang et al, 2004; Olive et al, 2004; Oren and Rotter, 2010; Terzian et al, 2008). Here, TP53 is linked to neoplasm.