Some missense mutations also confer a so-called gain-of-function (GOF) phenotype, converting mutant p53 into a cancer-promoting protein that renders cancer cells more malignant by increasing growth rate, motility, invasion, drug resistance, and tumorigenicity, while reducing the apoptotic rate (Blandino et al, 1999; Dittmer et al, 1993; Eliyahu et al, 1984; Muller and Vousden, 2013; Oren and Rotter, 2010; Peled et al, 1996; Vogelstein et al, 2000; Weisz et al, 2004; Wolf et al, 1984; Zalcenstein et al, 2003). Here, TP53 is linked to cancer.