Importantly, genetic ablation of FBXO42 also reduced the levels of p53 in the pancreatic cancer cell lines PANC-1 and Mia PaCa-2, which are homozygous for p53 R273H and p53 R248W (Redston et al, 1994), respectively (Fig. 2F; Appendix Fig. 3H), without affecting TP53 mRNA expression, confirming that FBXO42 acts on p53 via posttranscriptional regulation (Appendix Fig. 3I). This evidence concerns the gene TP53 and familial pancreatic carcinoma.