This observation may possibly confirm a clinical significance of KI-67/MIB-1 LI as a surrogate marker for the proliferative activity of glioma cells, as originally shown in comprehensive analyses on a cellular level, leading to the establishment of MIB-1 LI as the commonly used method for measuring the proliferative potential in human gliomas (Schröder et al. 1991; Kałuza et al. 1997; Thotakura et al. 2014). Here, MKI67 is linked to glioma.