MIB1 and central nervous system cancer: Although a correlation to histological grade in pediatric glioma has repeatedly been reported, several studies furthermore conformably show an association of KI-67/MIB-1 LI and PFS in pediatric high-grade glioma (Yao et al. 2023; Matsumoto et al. 1998; Pollack et al. 2002, 1997; Ho et al. 1998).