Beyond a characterization of MIB-1 LI values and analysis of a possible association with PFS and molecular data, we assess the correlation of MIB-1 LI values and pre- and postoperative tumor growth velocity, aiming to contribute to the understanding of the clinical implication and predictive value of MIB-1 LI as a surrogate marker of the proliferative activity in PLGG on progression-free survival. Here, MIB1 is linked to neoplasm.