TAMs promote tumor angiogenesis by secreting a plethora of pro-angiogenic growth factors, cytokines, and chemokines that induce EC proliferation and migration, including EGF[106], FGF-2/bFGF [107], platelet-activating factor (PAF) [108], PDGF [109], VEGF [110–112], TNF-α [113], IL-1 [114, 115], IL-8/CXCL8 [116, 117], and CCL18 [118]. Here, FGF2 is linked to neoplasm.