For instance, deletion of DNA methyltransferase 1 (DNMT1) in ECs inhibits tumor growth and reshapes the immune environment, due to the increased expression of cytokines, chemokines, cell adhesion molecules in ECs, such as Cxcl9 and Cxcl10 that are crucial for infiltration of CD8+ T cells into the tumor [89]. Here, CD8A is linked to neoplasm.