ANGPT2 and COVID-19: The markedly elevated levels of angiopoetin-1 (ANG1) in PACS patients may underline a long-term, wound-repairing angiogenic response due to the SARS-CoV2-associated endothelial injury [102], whereas increased angiopoietin-2 (ANG2) levels were associated to the fatal trajectory of COVID-19 reflecting the systemic microangiopathy by vascular disruption and remodeling in hospitalized COVID-19 patients ([96, 103].