Because we identified PSMD1 as a poor prognostic factor overexpressed in HCC, we compared the effects of its expression inhibition in HCC cells with distinct p53 statuses (Huh7, HepG2, Hep3B) and in several normal cells containing immortalized normal epithelial liver cells (THLE-2) to determine whether the inhibition of cell survival through PSMD1 depletion is more sensitive in cancer. This evidence concerns the gene TP53 and cancer.