For example, BCAAs metabolic reprogramming was exhibited in tumor tissues of both S-III and DEN and CCl4-induced HCC mouse models, but upregulation of BCAT1 and BCAT2 was detected in tumor tissues of S-III, whereas only upregulation of BCAT2 was detected in DEN and CCl4-induced HCC mouse model. This evidence concerns the gene BCAT2 and hepatocellular carcinoma.