The predictive value of the hub genes was assessed using ROC curves, and the aero under curves for CCDC167, POSTN, SEC14L1, and SERPINB2 were approximately 0.79, 0.87, 0.86, and 0.89, respectively, supporting their sensitivity and specificity in asthma diagnosis (Fig. 4E–H). This evidence concerns the gene POSTN and asthma.