The predictive value of the hub genes was assessed using ROC curves, and the aero under curves for CCDC167, POSTN, SEC14L1, and SERPINB2 were approximately 0.79, 0.87, 0.86, and 0.89, respectively, supporting their sensitivity and specificity in asthma diagnosis (Fig. 4E–H). The gene discussed is SERPINB2; the disease is asthma.