In a model of replicative senescence, GC exposure lead to altered methylation of GR target gene fkbp5, which was exacerbated by age, and the subsequently increased fkbp5 expression was associated with inflammation and myocardial infarction in humans, suggesting that GC is linked with age-related disease via a mechanism involving epigenetic regulation of fkbp576. The gene discussed is NR3C1; the disease is myocardial infarction.