It was found that ALB not only improves renal perfusion and glomerular filtration by prolonging renal vasodilation, but also selectively inhibits the expression of tumor necrosis factor-α-induced vascular cell adhesion molecule 1 and the activation of nuclear factor kB and monocyte adhesion in human endothelial cells to prevent kidney injury13,25.In T2DM patients, ALB level was negatively correlated with the incidence of diabetes retinopathy26. The gene discussed is ALB; the disease is type 2 diabetes mellitus.