In addition to this, we observed that these genes and nine others (OASL, RSAD2, ISG20, IFI16, IFIT1, CX3CR1, IFIT3, IRF7, and IFI27) exhibited more rapidly declining expression in COVID-19 severe sMetacells and reached plateaus below the expression in the sMetacells from patients with mild disease. The gene discussed is IFI27; the disease is COVID-19.