It should be noted that two non-synonymous coding cSNPs of the SULT2B1b variant in the SULT2B1 gene, c.446C > T (P149L) and c.821G > A (R274Q), have been previously reported to be involved in autosomal recessive ichthyosis (ARCI)28. This evidence concerns the gene SULT2B1 and autosomal recessive congenital ichthyosis.