AP-2αflox/flox/CDH5-Cre-ERT2 mouse was injected with tamoxifen to induce endothelium-specific AP-2α gene knockout (Supplementary Fig. 8B), which was followed by lovastatin administration prior to hyperlipidemia and hypertension (Supplementary Figs. 8B, C and Supplementary Table 3). This evidence concerns the gene MAPK3 and hyperlipidemia.