BRCA2 and tarsal-carpal coalition syndrome: Of all ten bladder risk candidate genes, only BRCA2 demonstrated higher missense variant presentation in TCC cats compared to unaffected cats (Fig. 3c) and at all positions (R1168C, H2394R, R2620G, S2833N, R3331K, D2392G), TCC cats expressed a heterozygous genotype.