Examples include SMIM30 in hepatocellular carcinoma47 and CDV3, in breast49,51 and colorectal adenosarcoma cancers48,49 In a recent pan-cancer study, CSMD2 was identified in 25 of 33 cancer types, with the highest expression found in gastric, lung, colorectal, and prostate cancer50. The gene discussed is CSMD2; the disease is cancer.