CRP and obesity due to melanocortin 4 receptor deficiency: However, patients’ global and pain assessments by VAS were higher in participants with obesity versus those without obesity (Patient Global by VAS 62±22 vs 57±24; Patient Pain by VAS 61±24 vs 56±24, respectively, both p=0.01, table 1), and participants with obesity had a slightly higher DAS28-CRP score (5.2±1.0 and 5.0±1.1, p=0.03, table 1).