CRP and obesity due to melanocortin 4 receptor deficiency: In survival analyses, participants with obesity at baseline were less likely to achieve response to treatment compared with those with BMI <30 kg/m2 (CDAI remission, adjusted HR 0.84, 95% CI 0.67 to 1.05; SDAI remission, HR 0.77, 95% CI 0.62 to 0.97; DAS28-CRP <2.6, HR 0.78, 95% CI 0.64 to 0.95; figure 4 and online supplemental table 2).