In total, 420 out of 793 participants had overweight or obesity (BMI ≥25 kg/m2).28 Participants with BMI ≥25 kg/m2 had a lower likelihood of achieving DAS28-CRP <2.6 compared with those with normal weight, and similar Kaplan-Maier curves are seen for CDAI and SDAI remission (online supplemental figure 4). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.