INS and type 2 diabetes mellitus: In addition to its impact on WAT and lipid uptake, GIP has also been shown to promote an increase in the translation of glucose transporter type 4 (GLUT4: a protein that aids in glucose uptake in AT in response to insulin) in 3T3-L1 adipocytes wild-type (WT) GIPR, or expressing E354Q GIPR, a mutation in the GIPR gene, a variant associated with insulin resistance, T2DM, and cardiovascular risk in humans.