GCG and type 1 diabetes mellitus: In the absence of insulin (patients with type 1 diabetes), however, glucagon administration causes an increase in plasma NEFA, glycerol and splanchnic ketone production (Liljenquist et al. 1974, Arafat et al. 2013); while suppression of glucagon by somatostatin leads to a decrease in free fatty acids and glycerol (Gerich et al. 1975).