Moreover, several other tumor metastasis-associated pathways have also been identified, including the KRAS (Kirsten rat sarcoma virus) signaling pathway (e.g. in tumor), coagulation (e.g. in tumor and immune cells), and interferon gamma response (e.g. in immune cells), when comparing Region 1 to the other regions (Supplementary Fig. S7). Here, KRAS is linked to neoplasm.