Comparing the cross-regional results from the two breast cancer patients in cancer epithelial, we identified several hallmark pathways enriched in both subjects, including fatty acid metabolism, xenobiotic metabolism, and TNFA (tumor necrosis factor) signaling via NF-κB (Nuclear factor-κB) (Fig. 4, details in the Supplementary Section S6). This evidence concerns the gene NFKB1 and breast carcinoma.