HIV compromises the immune system by targeting CD4+ T cells, impairing their function and reducing the body’s ability to fight infections.[23] Malaria, on the other hand, triggers a robust immune response, leading to inflammation and immune activation.[24] This interplay between HIV-induced immunosuppression and malaria-induced immune activation can exacerbate the severity and complications of both diseases. The gene discussed is CD4; the disease is malaria.