GLIS3 is a transcriptional regulator that regulates hedgehog signaling, a pathway involved in limb development and OA severity.[15] However, the factor itself is strongly associated with neonatal diabetes and congenital hypothyroidism, although single nucleotide polymorphisms around GLIS3 are associated with OA susceptibility.[16] This year, Zhang et al[17] confirmed similar OA associations in Chinese population (rsl0116772, rs7045410, and rs7032713). The gene discussed is GLIS3; the disease is congenital hypothyroidism.