The top 5 genes obtained by the MCC algorithm in Cytohubba were all immune inflammation-related genes (IL1B, TNF, PTGS2, CASP3, IFNG), which is consistent with previous studies that inflammation is an important pathogenesis of HF, and the mechanism of SGC for HF treatment is focused on the regulation of immune inflammation. This evidence concerns the gene CASP3 and hydrops fetalis.