IL10 and Atherosclerotic lesion: On the other hand, Th2 response showed an antiatherogenic trend by producing IL4, IL-5, and IL-10.[53] Regulatory T cells (Tregs), which are capable of producing inhibitory cytokines such as IL-10 and TGF-β, have been identified in the development of atherosclerosis and have been shown to play a role in inhibiting progression through modulation of lipoprotein metabolism.[54] B cells, another kind of important adaptive immune cells, are relatively uncommon in atherosclerotic lesions.