Using the IVW method, the odds ratio (OR) of HLA-DR on CD14+ monocytes for the risk of IBD was estimated to be 0.902 (95% confidence interval [CI]: 0.859–0.947, P = 4.18 × 10–5; Supplementary Table S1, http://links.lww.com/MD/M12, Fig. 3). This evidence concerns the gene CD14 and inflammatory bowel disease.