It is related to the occurrence, development,[14] metastasis and prognosis of cancer.[15] Inflammatory status can be reflected by corresponding serum indexes, such as C-reactive protein,[16] erythrocyte distribution width,[17] erythrocyte sedimentation rate,[18] etc. The neutrophil-to-lymphocyte ratio (NLR) is considered to be an indicator of inflammatory response in cancer patients.[19] Because of its convenient availability, it has high clinical significance.[20]. The gene discussed is CRP; the disease is cancer.