ATD refers to patients whose AT activity levels are consistently below 80% (or the lower limit of the reference range of the test) and can be divided into acquired ATD and hereditary ATD.[6] Hereditary ATD is mostly caused by mutations in the coding gene of AT—SERPINC1, till now, hundreds of SERPINC1 mutations have been identified. Here, SERPINC1 is linked to Jeune syndrome.