The leptin–Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway was reported to increase fatty acid oxidation through the transcription of metabolic gene CPT1B, supporting cancer stemness and chemoresistance in multiple TNBC models including MDA-MB-231 cells treated with paclitaxel (30). Here, STAT3 is linked to cancer.