For each disease, we first searched for literature evidence about the top 15 predicted targets unobserved in the known biological networks (Tables G and H in S1 Text) and then chose six target candidates that lacked existing literature support for further experimental validation, including HSP90AB1, RPS6KB1, and MME for melanoma, and ADCY5, ADRA2A, and EEF2 for CRC. The gene discussed is ADRA2A; the disease is colorectal carcinoma.